Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 8, Pages 1247-1252Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000825
Keywords
aromatic substitution; copper; cross-coupling; retro reactions; trifluoromethylation
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Science and Technology Agency
- Ube Foundation
- Asahi Glass Foundation
- Naito Foundation
- Astellas Foundation
- Grants-in-Aid for Scientific Research [22106531, 22350043] Funding Source: KAKEN
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Starting from a readily available fluoral derivative, catalytic aromatic trifluoromethylation has been successfully achieved. A small amount of copper(I) iodide-phenanthroline complex catalyzed the cross-coupling reactions of aryl/heteroaryl iodides with the O-silylated hemiaminal of fluoral (trifluoroacetaldehyde) to provide trifluoromethylated arenes in moderate to high yields.
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