4.7 Article

One-Pot Synthesis of Triazolothiadiazepine 1,1-Dioxide Derivatives via Copper-Catalyzed Tandem [3+2] Cycloaddition/N-Arylation

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 1, Pages 41-48

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000465

Keywords

copper(I) iodide; fused triazoles; one-pot porcess; sultams; triazolothiadiazepine 1,1-dioxides

Funding

  1. National Science Council of the Republic of China
  2. National Taiwan Normal University [99T3030-2, 99D]
  3. MOFA

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A practical and efficient synthesis of triazolothiadiazepine-1,1-dioxide derivatives via copper-catalyzed [3+2] cycloaddition, followed by N-arylation is described. The method is also applicable to the synthesis of indoline- and thiophene-fused triazolothiadiazepine 1,1-dioxide derivatives.

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