4.7 Article

Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One-Pot Cascade Reaction

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 2-3, Pages 343-348

Publisher

WILEY-BLACKWELL
DOI: 10.1002/adsc.201000647

Keywords

asymmetric catalysis; cascade reactions; one-pot process; oxazolidines; vinyl aldehydes

Funding

  1. National Natural Science Foundation of China [20902018]
  2. Fundamental Research Funds for the Central Universities
  3. Shanghai Pujiang Program [08J1403300]
  4. 111 project [B07023]

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An asymmetric organocatalytic cascade reaction which can afford a series of oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.

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