Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 9, Pages 1443-1446Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100143
Keywords
aldol reaction; asymmetric synthesis; green chemistry; L-proline catalyst; organocatalysis
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A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol reactions, is presented. Excellent results, in terms of chemical yields and diastereo-/enantiomeric ratios, are reported for the catalyzed additions of cyclohexanone to variously substituted benzaldehydes.
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