Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 9, Pages 1429-1437Publisher
WILEY-BLACKWELL
DOI: 10.1002/adsc.201100038
Keywords
cyclization; fused benzimidazoles; iodine; silver nitrate
Categories
Funding
- National Natural Science Foundation of China [21021063, 20872153, 81025017]
Ask authors/readers for more resources
A protocol for the synthesis of the fused heterocyclic polycyclic compounds pyrrole[1,2-a]benzimidazoles, piperidine[1,2-a]benzimidazoles and oxa-fused benzimidazoles using iodine and silver nitrate by an exo-dig or endo-dig cyclization pathway at room temperature has been developed. Silver nitrate is a key additive for improving the yield, and the improvement is a result of this additive eliminating the influence of iodine ions (I(-)), which would otherwise lead to the formation of bis-iodine by-products. Cyclizations involving terminal and substituted alkynes were performed. Further functionalizations demonstrated that the iodo derivatives obtained are potential synthetic intermediates that can increase the molecular complexity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available