4.7 Article

Multicomponent Synthesis of 1,2,3-Triazoles in Water Catalyzed by Copper Nanoparticles on Activated Carbon

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 18, Pages 3208-3214

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000637

Keywords

click chemistry; copper nanoparticles; cycloaddition; heterogeneous catalysis; triazoles; water

Funding

  1. Spanish Ministerio de Ciencia e Innovacion (MICINN) [CTQ2007-65218, 2010-CSD2007-00006]
  2. Generalitat Valenciana (GV) [PROMETEO/2009/039]
  3. Vicerrectorado de Investigacion, Desarrollo e Innovacion of the Universidad de Alicante

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Copper nanoparticles on activated carbon have been found to effectively catalyze the multicomponent synthesis of 1,2,3-triazoles from different azide precursors, such as organic halides, diazonium salts, anilines and epoxides in water. The first one-pot transformation of an olefin into a triazole is also described. The catalyst is easy to prepare, very versatile and reusable at a low copper loading.

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