Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 2-3, Pages 416-424Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900630
Keywords
bifunctional thioureas; Michael addition reaction; nitroolefins; organocatalysis; oxindoles
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Funding
- Natural Science Foundation (NSFC) [20632000, 20702052, 20902091]
- MOST [2008CB617501, 2009ZX09501-018]
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A simple alkylthiourea was found to be an effective catalyst for the Michael addition reaction of 3-substituted oxindole to nitroolefins. A number of 3,3'-substituted oxindole derivatives, which have two vicinal quaternary-tertiary chiral centers were synthesized with up to 99% yields 19:1 dr and 98% ee.
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