4.7 Article

Lewis Acid-Catalyzed C-H Functionalization for Synthesis of Isoindolinones and Isoindolines

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 18, Pages 3195-3200

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000556

Keywords

C-H functionalization; isoindolines; isoindolinones; Lewis acids; tandem reactions

Funding

  1. National Natural Science Foundation of China [20802085, 20625308]
  2. Chinese Academy of Sciences

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The Lewis acid-catalyzed C-H functionalization of 2-substituted azaarenes with N-sulfonylaldimines has been developed, which provides a rapid and efficient approach for synthesis of heterocycle-containing isoindolinones and isoindolines.

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