Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 16, Pages 2745-2750Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000545
Keywords
aldehydes; combination catalysis; enantioselectivity; ketones; trifluoromethylation
Categories
Funding
- National Natural Science Foundation of China [20772091, 20902067]
- Tianjin Municipal Science & Technology Commission [08JCYBJC09500]
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The application of combination catalysis in enantioselective trifluoromethylation reactions is illustrated. Four ground-breaking studies have described the efficient catalytic enantioselective nucleophilic trifluoromethylation of ketones and azomethine imines in the presence of the combination of a Cinchona alkaloid-derived ammonium salt and different nucleophilic initiators, whereas the highly enantioselective electrophilic and radical trifluoromethylation of aldehydes could be achieved via the combination of chiral organocatalysts and metal salts.
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