4.7 Article

Improved Radical Approach to N-Unsubstituted Indol-2-one and Dihydro-2-quinolinone Compounds Bearing Spirocyclic Cyclohexanone/Cyclohexadienone Rings

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 13, Pages 2275-2280

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000067

Keywords

azides; cyclization; radical reactions; silanes; spiro compounds

Funding

  1. University of Bologna
  2. MIUR

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N-Unsubstituted indol-2-one and 3,4-dihydro-2-quinolinone compounds bearing spirocyclic cyclohexanone/cyclohexadienone rings can be accessed through a novel, improved method entailing the key radical spirocyclization of easily accessible N-methoxymethyl (MOM)-protected 2-iodoanilides derived from 4-azidobenzoic and 2-(4-azidophenyl) acetic acid.

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