4.7 Article

A Bifunctional Cinchona Alkaloid-Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans-Chalcones

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 13, Pages 2137-2141

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000334

Keywords

asymmetric catalysis; bifunctional organocatalyst; squaramides; sulfa-Michael addition

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A chiral squaramide catalysts-promoted asymmetric sulfa-Michael conjugated addition of thiols to trans-chalcones is presented. Moderate to excellent yields and high enantioselectivities (up to 99% ee) were achieved under mild conditions.

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