Practical Iron-Catalyzed Allylations of Aryl Grignard Reagents

An operationally simple iron-catalyzed reductive cross-coupling reaction between aryl halides and allyl electrophiles has been developed. The underlying domino process exhibits high versatility with respect to the allylic leaving group (acetate, tosylate, diethyl phosphate, methyl carbonate, trime-thylsilanolate, methanethiolate, chloride, bromide) and high economic and environmental sustainability with respect to the catalyst system (0.2-5 mol% tris(acetylacetonato) iron(III), ligand-free) and reaction conditions (tetrahydrofuran, 0 degrees C, 45 min).