Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 1, Pages 119-124Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900671
Keywords
alkyl bromides; aryl halides; polyethylene glycol; thioarylation; thioetherification; thioureas
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Funding
- Shiraz University Research Council
- TWAS Chapter of Iran
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In this article, we have developed a new protocol for the thioarylation of structurally diverse alkyl bromides such as benzyl, cinnamyl, n-octyl, cyclohexyl, cyclopentyl, and tert-butyl bromides with aryl iodides, bromides and an activated chloride using thiourea catalyzed by copper(I) iodide in wet polyethylene glycol (PEG 200) as an eco-friendly medium in the presence of potassium carbonate at 80 and 100 degrees C under an inert atmosphere. The process is free from foul-smelling thiols which makes this method more practical for the thioetherification of aryl halides. Another important feature of this method is the variety of alkyl bromides which are commercially available for the in situ generation of thiolate ions with respect to the existing protocols in which the less commercially available thiols are directly used for the preparation of arylthio ethers.
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