Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 1, Pages 195-200Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900844
Keywords
antiviral agents; asymmetric synthesis; biotransformations; oxidative transposition; synthesis design; tamiflu synthesis
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- TDC Research, Inc.
- Brock University
- Research Corporation
- Ontario Partnership for Innovation and Commercialization (OPIC)
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A short chemoenzymatic and azide-free synthesis of oseltamivir was attained with the key steps consisting of a one-pot Dauben-Michno oxidative transposition and amination and a reductive transposition of an acrylate.
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