4.7 Article

Palladium-Catalyzed Asymmetric Hydrogenation of Simple Ketimines Using a Bronsted Acid as Activator

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 1, Pages 84-88

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000554

Keywords

asymmetric hydrogenation; Bronsted acids; ketimines; palladium catalysis

Funding

  1. National Science Foundation of China [20872140, 20921092]
  2. Chinese Academy of Sciences

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Using a catalytic amount of a Bronsted acid as activator of simple imines, the highly enantioselective homogeneous palladium-catalyzed asymmetric hydrogenation of simple ketimines was successfully developed with up to 95% ee.

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