4.7 Article

Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 10, Pages 1582-1586

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000180

Keywords

copper; coupling reactions; cyclization; fluorinated alkynylimines; fluorinated quinolines

Funding

  1. National Science Foundation of China [20772145]

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2-Fluoromethylated quinolines were synthesized through the reaction of N-aryl-fluorinated imidoyl iodides with terminal alkynes in good yields by the catalysis of copper(I) iodide (CuI) alone.

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