Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 8, Pages 1296-1300Publisher
WILEY-BLACKWELL
DOI: 10.1002/adsc.200900875
Keywords
cascade reactions; C-N cross-coupling; copper; quinoxalines; trifluoromethyl substituents
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Funding
- National Science Foundation of China [20532040, 20772145]
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Novel tricyclic 4-(trifluoromethyl)-[1,2,3]triazolo[1,5-a]quinoxalines were readily prepared from N-(o-haloaryl)alkynylimines and sodium azide via copper(I)-catalyzed tandem reactions. This synthetic strategy provides an efficient way to access a library of novel heterocyclic compounds that are of interest in drug discovery.
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