Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 351, Issue 18, Pages 3027-3043Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900587
Keywords
C-C bond formation; C-N bond formation; cross coupling; homogeneous catalysis; industrial-scale processes; palladium
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Funding
- State of Mecklenburg-Western Pomerania
- Bundesministerium fur Bildung und Forschung (BMBF)
- Deutsche Forschungsgemeinschaft (DFG)
- Evonik Degussa
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Palladium-catalyzed coupling reactions have become a central tool for the synthesis of biologically active compounds both in academia and industry. Most of these transformations make use of easily available substrates and allow for a shorter and more selective preparation of substituted arenes and heteroarenes compared to non-catalytic pathways. Notably, molecular-defined palladium catalysts offer high chemoselectivity and broad functional group tolerance. Considering these advantages, it is not surprising that several palladium-catalyzed coupling reactions have been implemented in the last decade into the industrial manufacture of pharmaceuticals and fine chemicals. In this review different examples from 2001-2008 are highlighted, which have been performed at least on a kilogram scale in the chemical and pharmaceutical industries.
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