Efficient Method for the Synthesis of Optically Active 2-Amino-2-chromene Derivatives via One-Pot Tandem Reactions

The asymmetric synthesis of functionalized 2-amino-2-chromene derivatives with high enantioselectivities via one-pot tandem reactions of functionalized alpha,beta-unsaturated ketones with malononitrile catalyzed by 9-amino-9-deoxyepiquinine (1a) in combination with (R)-1,1'-binaphth-2,2'-diyl hydrogen phosphate (1c) is reported for the first time.