Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 351, Issue 4, Pages 649-655Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800783
Keywords
aryldiazonium tetrafluoroborates; palladium on activated charcoal; practical cross-coupling; sustainable chemistry; Suzuki-Miyaura reaction
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Funding
- Universite de Bordeaux
- Centre National de la Recherche Scientifique (CNRS)
- Evonik Degussa GmbH
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An improved Suzuki-Miyaura cross-coupling reaction of aryldiazonium tetrafluoroborates with boronic acids catalyzed by a highly active palladium catalyst supported on charcoal is described as an extremely practical and efficient protocol. A properties-activity study of various catalysts clearly established that the optimal catalytic activity was obtained with palladium nanoparticles having a low oxidation degree and uniformly dispersed on the charcoal. The optimized reaction conditions allow the cross-coupling to proceed at room temperature without any base and ligand in technical grade methanol. Although the catalyst could not be recycled. the low palladium contamination of the solvent and product after a simple filtration of the palladium on charcoal (Pd/C) renders the present protocol competitive and safer for the environment compared to more conventional homogeneous conditions. We have highlighted the efficiency of this novel protocol by a short synthesis of the fungicide Boscalid (R).
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