Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 351, Issue 3, Pages 375-378Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800645
Keywords
asymmetric catalysis; fluorine; hydrogenation; iridium; P,N ligands
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Funding
- The Swedish Research Council
- Ligbank [FP6-505267-1]
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Fluorine-containing compounds are useful in many applications ranging from pharmaceuticals to ferroelectric crystals. We have developed a new, highly enantioselective synthetic route to trifluoromethyl-bearing stereocenters in up to 96% ee via asymmetric hydrogenation using N,P-ligated iridium catalysts. We also hydrogenated an isomeric mixture of olefins; this reaction gave the hydrogenation product highly enantioselectively (87% ee), and only the E isomer was present after the reaction had reached 56% conversion.
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