A Dual Gold-Iron Catalysis for a One-Pot Synthesis of 2,3-Dihydroisoxazoles from Propargylic Alcohols and N-Protected Hydroxylamines

A concise one-pot route for the synthesis of 2,3-dihydroisoxazoles via a dual gold-iron catalysis has been devised. The method, based on the addition of binucleophilic protected hydroxylamine to propargylic alcohols, enables a one-pot, highly selective synthesis of these heterocycles (10 examples, up to 86% yield).