4.7 Article

Homobenzotetramisole-Catalyzed Kinetic Resolution of α-Aryl-, α-Aryloxy-, and α-Arylthioalkanoic Acids

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 351, Issue 14-15, Pages 2301-2304

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900451

Keywords

acylation; anhydrides; carboxylic acids; kinetic resolution

Funding

  1. NIGMS [NIH R01 GM072682]
  2. NIH [P41RR0954]

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Effective kinetic resolutions of alpha-aryl-, alpha-aryloxy-, and alpha-arylthioalkanoic acids have been achieved via in situ generation of their symmetrical anhydrides and enantioselective alcoholysis in the presence of homobenzotetramisole (HBTM) 3.

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