Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 350, Issue 7-8, Pages 1081-1089Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800007
Keywords
asymmetric hydrogenation; homogeneous catalysis; iridium; phosphoramidites; quinolines
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The monodentate BINOL-derived phosphoramidite PipPhos is used as ligand for the iridium-catalyzed asymmetric hydrogenation of 2- and 2,6-substituted quinolines. If tri-ortho-tolylphosphine and/or chloride salts are used as additives enantioselectivities are strongly enhanced up to 89%. NMR indicates that no mixed complexes are formed upon addition of tri-ortho-tolylphosphine.
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