Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 350, Issue 14-15, Pages 2365-2372Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200800364
Keywords
atom transfer radical addiiton (ATRA); copper; Kharasch reaction; radical reactions; trispyrazolylborate ligands
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Funding
- MEC [CTQ2005-00324BQU]
- Junta de Andalucia [P07-FQM-02794]
- Universidad de Huelva
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The reaction of carbon tetrachloride (CCl4) with various 1,6-heptadienes catalyzed by copper homoscorpionate complexes affords cyclization products in moderate to high yields. The process involves the addition of the trichloromethyl radical to the diene followed by a 5-exo-trig cyclization reaction, resulting in the formation of the cis-3-chloromethyl-4-(2,2,2-trichloroethyl)cyclopentane isomers in a highly regiospecific and stereospecific manner. We have studied the use of magnesium (Mg) as reducing agent for the regeneration of copper(I) catalysts. This method has afforded heterocycles in high yields even in the cases of diallyl ether (DAE) and tert-butyl NN-diallylcarbamate (TBDAC).
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