Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 350, Issue 9, Pages 1267-1270Publisher
WILEY-BLACKWELL
DOI: 10.1002/adsc.200800111
Keywords
aldol reaction; amino acids; asymmetric synthesis; ionic liquids; organic catalysis
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A remarkable improvement of both the chemical yield (from 6% to 82%) and the enantiomeric excess (up to > 99%), of (S)-proline catalyzed direct aldol reactions of a wide range of aldehydes with acetone was found when hexasubstituted or pentasubstituted guanidinium salts were added as ionic liquids. Effects of temperature, amount of proline and the type of guandidinium salts on the outcome of the reaction were investigated.
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