Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 350, Issue 9, Pages 1295-1308Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700388
Keywords
asymmetric catalysis; cyclopropanation; immobilization; packed bed reactor; siliceous mesocellular foam
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Aza(bisoxazoline) was easily immobilized on siliceous mesocellular foam (MCF) in a systematic approach. It was found that silanol precapping, linker group flexibility, ligand loading, and silanol postcapping were important factors to consider in optimizing silica-supported aza(bisoxazoline) catalysts. The optimized MCF-supported aza(bisoxazoline)-copper catalyst offered the same enantioselectivity as its homogeneous counterpart, and excellent recyclability. The heterogenized catalyst showed a much higher chemoselectivity in a short reaction time. The heterogenized aza(bisoxazoline)-copper(I) catalyst was successfully applied to a circulating flow-type packed bed reactor with excellent productivity and enantioselectivity. The circulating flow-type reactor was found to be very useful for gas-generating catalytic reactions such as cyclopropanation reaction.
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