HYPOGLYCEMIC EFFECTS OF METHANOLIC EXTRACT OF ANTHOCEPHALUS CADAMBA BARK IN ALLOXAN INDUCED DIABETIC RATS (ROX B) MIQ.

In view of the ethanobotanical and traditional claims of Anthocephalus cadamba plant used as hypoglycemic agent and wide use of its bark, fruits and leaf extract in anti-diabetic activity. Methanolic extract of Anthocephalus cadamba bark in alloxan induce hypoglycemia in rats. In glucose loaded normal rats, hypoglycemia was observed maximum at 120 minutes after administration of ACBE (Anthocephalus cadamba bark extract). Single dose administration of ACBE produce significant hypoglycemic effect in alloxan induced diabetic rats. The present study indicates that the methanol extract of barks posses anti-diabetic properties which suggest the presence of biologically active components. The extract might be promoting glucose uptake and metabolism or inhibiting hepatic gluconeogenesis. Result from the phytochemical analysis of Anthocephalus cadamba revealed the presence of flavonoids, which has also been isolated from the other plant and found to stimulate secretion or possess an insulin-like effect.