Preparation and Biofunctionalization of Multicolor Conjugated Polymer Nanoparticles for Imaging and Detection of Tumor Cells

Multicolor conjugated polymer nanoparticles (CPNs) are designed and bio-functionalized with antibody for targeted cell imaging and cell detection. In comparison to single-antibody recognition mode to tumor cells, enhanced specificity for targeted imaging and detection of tumor cells is achieved by binding two antibody functionalized CPNs to one tumor cell. This strategy provides a new platform for designing CPNs useful for targeted imaging, cells detection and other biological applications.