Journal
ADVANCED MATERIALS
Volume 27, Issue 3, Pages 576-585Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201401124
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Funding
- State Key Laboratory of Oncogenes and Related Genes [91-14-03]
- High Tech Program of MOST China [2013AA032203]
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Advances in nanotechnology and nanomedicine offer great opportunities for the development of nanoscaled theranostic platforms. Among various multifunctional nanocarriers, magnetic mesoporous silica nanocomposites (M-MSNs) attract prominent research interest for their outstanding properties and potential biomedical applications. This Research News article highlights recent progress in the design of core-shell-type M-MSNs for both diagnostic and therapeutic applications. First, an overview of synthetic strategies for three representative core-shell-type M-MSNs with different morphologies and structures is presented. Then, the diagnostic functions of M-MSNs is illustrated for magnetic resonance imaging (MRI) applications. Next, magnetic targeted delivery and stimuli-responsive release of drugs, and effective package of DNA/siRNA inside mesopores using M-MSNs as therapeutic agent carriers are discussed. The article concludes with some import ant challenges that need to be overcome for further practical applications of M-MSNs in nanomedicine.
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