Journal
ADVANCED MATERIALS
Volume 26, Issue 41, Pages 7019-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201402572
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Funding
- Australian Research Council through its DP
- Future Fellowship scheme
- National Nature Science Foundation of China [51302293, 51132009]
- Shanghai Rising-Star Program [14QA1404100]
- Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201203]
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Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T-1-weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells.
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