Journal
ADVANCED MATERIALS
Volume 27, Issue 8, Pages 1402-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201404788
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Funding
- MOST [2013AA032204, 2013YQ190467]
- NSFC [21475028, 51105086, 21025520, 81361140345, 11422215, 11272327, 11023001]
- Beijing Municipal Science & Technology Commission [Z131100002713024]
- Chinese Academy of Sciences [XDA09030305, XDA09030308]
- CAS/SAFEA International Partnership Program for Creative Research Teams
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Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
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