4.8 Article

Single-Layer Transition Metal Dichalcogenide NanosheetBased Nanosensors for Rapid, Sensitive, and Multiplexed Detection of DNA

Journal

ADVANCED MATERIALS
Volume 27, Issue 5, Pages 935-939

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201404568

Keywords

DNA; fluorescence; multiplexed detection; nanosheets; transition metal dichalcogenides

Funding

  1. State Plan for Development of Basic Research in Key Areas [2012CB933301]
  2. Ministry of Education of China [IRT1148]
  3. National Natural Science Foundation of China in China [61205195]
  4. Singapore MOE under AcRF [ARC 26/13, MOE2013-T2-1-034, RG 61/12, RGT18/13, RG5/13, M4080865.070.706022]
  5. Singapore Millennium Foundation
  6. National Research Foundation, Prime Minister's Office, Singapore

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Single-layer transition metal dichalcogenide nanosheets, including MoS2, TiS2, and TaS2, are used as novel sensing platforms for sensitive and selective detection of DNA, based on their high fluorescence-quenching ability and different affinities toward single-stranded DNA and double-stranded DNA. Importantly, for the first time, a single-layer TaS2 nanosheet-based multiplexed DNA sensor is also developed.

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