4.8 Article

Multifunctional Smart Particles Engineered from Live Immunocytes: Toward Capture and Release of Cancer Cells

Journal

ADVANCED MATERIALS
Volume 27, Issue 2, Pages 310-313

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201402213

Keywords

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Funding

  1. National Research Fund for Fundamental Key Projects [2012CB933800, 2013CB933000, 2012CB934100]
  2. National Natural Science Foundation [21121001, 21127025, 21175140, 20974113]
  3. Key Research Program of the Chinese Academy of Sciences [KJZD-EW-M01]
  4. National High Technology Research and Development Program of China (863 Program) [2013AA031903]
  5. China Postdoctoral Science Foundation [2014M550847]

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Multifunctional smart particles with magnetic, topographic, cell-targeting, and stimulus-responsive properties are obtained using a live template strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enable the release of captured cells with high viability via reduction of disulfide bonds. Diverse multifunctional particles can be designed using the live template strategy.

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