Journal
ADVANCED MATERIALS
Volume 27, Issue 5, Pages 903-910Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201404308
Keywords
human serum albumin; indocyanine green; paclitaxel; combination therapy; lung metastasis
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Funding
- National Basic Research Programs of China (973 Program) [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51222203, 51132006]
- Jiangsu Natural Science Fund for Distinguished Young Scholars
- Jiangsu Key Laboratory for Carbon-Based Functional Materials Devices
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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A new Abraxane-like nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-ofconcept study.
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