Journal
ADVANCED MATERIALS
Volume 26, Issue 29, Pages 4961-4966Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201400154
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Funding
- National Institutes of Health [5R01DE015633, 5R01HL092526, 1R21EB015190, 4R03AR056848]
- National Science Foundation [CBET-0854465, CMMI-1234957, CBET-0854414, DMR-0847758]
- Oklahoma Center for Adult Stem Cell Research [434003]
- Department of Defense Peer Reviewed Medical Research Program [W81XWH-12-1-0384]
- Oklahoma Center for the Advancement of Science and Technology [070014, HR11-006]
- National High Technology Research and Development Program 863 [2013AA102507]
- National Natural Science Foundation of China [20804037, 21172194]
- Zhejiang Provincial Natural Science Foundation of China [LZ12C17001]
- Projects of Zhejiang Provincial Science and Technology Plans [2012C12910]
- Silkworm Industry Science and Technology Innovation Team [2011R50028]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1234957] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [847758] Funding Source: National Science Foundation
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A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
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