Journal
ADVANCED MATERIALS
Volume 26, Issue 5, Pages 712-717Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201302365
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Funding
- State High-Tech Development Plan [2012AA020804]
- National Natural Science Foundation of China [30970784, 31170873, 81171455]
- National Key Basic Research Program of China [2009CB930200]
- National Distinguished Young Scholars grant from the National Natural Science Foundation of China [31225009]
- Chinese Academy of Sciences (CAS) Hundred Talents Program [07165111ZX]
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Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.
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