Journal
NANO LIFE
Volume 1, Issue 1-2, Pages 79-87Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793984410000079
Keywords
Protein-protein interaction; bioluminescence; luciferase; complementation
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Japan Science and Technology Corporation (JST)
- New Energy Industrial Technology Development Organization (NEDO)
- MEXT, Japan [S0801035]
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Many imaging technologies based on luminescent proteins have proven useful for detecting protein-protein interactions, tracking cells in mice, and monitoring transcriptional regulation of specific genes. Especially, novel bioluminescent proteins have advanced the study of induced protein interactions and protein modification in live cells and animals. This review focuses on recent developments of bioluminescent probes for quantitative evaluation of specific protein-protein interactions and their spatio-temporal imaging by means of split luciferase complementation techniques. From the comparison between fluorescent and bioluminescent proteins, advantages and drawbacks of the bioluminescence techniques are described.
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