Journal
ADVANCED MATERIALS
Volume 25, Issue 39, Pages 5609-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201302842
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Funding
- National Heart Lung and Blood Institute of the National Institutes of Health [HHSN268201000046C]
- National Science Foundation [DMR-1105304]
- Welch Foundation through the W. T. Doherty-Welch Chair in Chemistry [A-0001]
- NIH [P30 DC004665]
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A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.
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