Journal
ADVANCED MATERIALS
Volume 25, Issue 16, Pages 2368-2373Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201300082
Keywords
cancer diagnosis; circulating tumor cells; nanostructured materials; aptamer; cell capture; cell release
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Funding
- Creativity Award from Prostate Cancer Foundation
- NIH/NCI Innovative Molecular Analysis Technologies (IMAT) Program [R21 CA151159, R33 CA157396]
- Chinese Academy of Sciences
- National Basic Research Program of China [2011CB911001]
- NSFC [21121063]
- National High Technology Research and Development Program Grant of China [2012AA02A502]
- China Scholarship Council of the Ministry of Education of the P. R. China
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A platform for capture and release of circulating tumor cells (CTCs) is demonstrated by utilizing aptamer grafted silicon nanowires. Here, single-stranded DNA-aptamers are generated via the Cell-SELEX process to serve as capture agents, allowing specific capture and release of non-small cell lung cancer (NSCLC) CTCs from whole-blood samples with minimum contamination and negligible disruption to CTC viability and functions.
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