Journal
ADVANCED MATERIALS
Volume 25, Issue 25, Pages 3426-3431Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201300188
Keywords
biolubrication; sjogren's syndrome; protein therapeutics; scanning force microscopy; supercharged polypeptides
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Funding
- EU (ERC starting grant NUCLEOPOLY)
- NWO (VICI grant)
- Zernike Institute for Advanced Materials
- ZonMw [91107008]
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Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.
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