Journal
ADVANCED MATERIALS
Volume 24, Issue 6, Pages 749-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201103828
Keywords
biomedical applications; biomineralization; bionanotechnology; tissue engineering; composite materials
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Funding
- European Research Council under the European Community [FP7/2007-2013, 239685]
- Science Foundation Ireland [04/Yl1/B531]
- Grants-in-Aid for Scientific Research [21390533] Funding Source: KAKEN
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The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.
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