4.8 Article

Capture and Stimulated Release of Circulating Tumor Cells on Polymer-Grafted Silicon Nanostructures

Journal

ADVANCED MATERIALS
Volume 25, Issue 11, Pages 1547-1551

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201203185

Keywords

cancer diagnosis; circulating tumor cells; nanostructured materials; thermally responsive polymers; cell capture; cell release

Funding

  1. Prostate Cancer Foundation
  2. National Institute of Health [R21 CA151159, R33 CA157396]
  3. RIKEN Advanced Science Institute
  4. JSPS/MEXT [22681016, 23700565, 23710138]
  5. Grants-in-Aid for Scientific Research [23700565, 22681016, 23710138] Funding Source: KAKEN

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A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.

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