4.8 Article

Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

Journal

ADVANCED MATERIALS
Volume 24, Issue 13, Pages 1722-1728

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201104864

Keywords

Alzheimer's disease; amyloid; graphene; nanomaterials; phototherapy

Funding

  1. 973 Project [2011CB936004, 2012CB720602]
  2. NSFC [20831003, 90813001, 20833006, 20903086, 90913007]
  3. CAS

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A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin-S (ThS)modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side effects and improved selectivity and safety.

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