Journal
ADVANCED MATERIALS
Volume 24, Issue 46, Pages 6175-6180Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202847
Keywords
drug delivery; bacteria-responsive; methicillin-resistant S; aureus; nanogel; zebrafish
Categories
Funding
- National Basic Research Program of China (973 Programs) [2010CB934001, 2009CB930301]
- National Natural Science Foundation of China [51125012, 20974105]
- Open Project of State Key Laboratory of Supramolecular Structure and Materials [SKLSSM201201]
- Fundamental Research Funds for the Central Universities [WK2070000008]
Ask authors/readers for more resources
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
