4.8 Article

Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography

Journal

ADVANCED MATERIALS
Volume 24, Issue 31, Pages 4266-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202024

Keywords

extracelluar microenviroment; cell culture; soft material; optical projection stereolithography; maskless lithography

Funding

  1. National Institute of Biomedical Imaging And Bioengineering [R01EB012597]
  2. National Science Foundation [CMMI-1130894, CMMI-1120795]
  3. U.S. National Science Foundation I2CAM International Materials Institute Award
  4. National Natural Science Foundation of China [51028501]
  5. UCSD [P30 (NS047101)]
  6. [DMR-0844115]
  7. Direct For Mathematical & Physical Scien
  8. Division Of Materials Research [844115] Funding Source: National Science Foundation
  9. Div Of Civil, Mechanical, & Manufact Inn
  10. Directorate For Engineering [1120795, 1130894] Funding Source: National Science Foundation

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The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digitalmirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.

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