Journal
ADVANCED MATERIALS
Volume 24, Issue 6, Pages 785-+Publisher
WILEY-BLACKWELL
DOI: 10.1002/adma.201104033
Keywords
Nanocapsules; Silica; Imaging techniques
Categories
Funding
- National Basic Research Program of China (973 Program) [2011CB707905]
- National Natural Science Foundation of China [51072212, 51132009]
- Science and Technology Commission of Shanghai [10QH1402800, 11nm0506500]
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An inorganic enhancement agent ( EA) for high-intensity focused ultrasound (HIFU) imaging based on mesoporous silica nanocapsules is presented. The pronounced coagulative necrosis effects demonstrate, both in vitro and in vivo, that the EA can be developed as a highly promising theranostic agent for effective HIFU imaging and therapy owing to its high stability, efficient perfluorohexane loading and release, enhanced tumor ablation capability, and easy uptake by target tissues.
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