4.8 Article

A Sensitive H2O2 Assay Based on Dumbbell-like PtPd-Fe3O4 Nanoparticles

Journal

ADVANCED MATERIALS
Volume 25, Issue 1, Pages 132-136

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201203218

Keywords

PtPd alloy nanoparticles; Iron oxide nanoparticles; dumbbell nanoparticles; synergistic effect; H2O2 assay

Funding

  1. DOE [DE-FG02-07ER46374]

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Dumbbell-like Pt48Pd52-Fe3O4 nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H2O2 reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt48Pd52-Fe3O4/TMB kit is even more active than the natural enzyme for H2O2 detection with a detection limit reaching 2 mu M, and is successfully used to quantitatively monitor the extracellular H2O2 generated by neutrophils.

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