Journal
ADVANCED MATERIALS
Volume 24, Issue 48, Pages 6433-6437Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201201742
Keywords
coordination bond; pH-responsive nanoparticles; mesoporous silica; coordination polymers; drug delivery
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Funding
- 973 project of China [2009CB930403]
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Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H+ stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
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