Journal
ADVANCED MATERIALS
Volume 24, Issue 42, Pages 5755-5761Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201202433
Keywords
luminescence; magnetic resonance imaging; nanoparticles; photodynamic therapy; upconversion
Categories
Funding
- National Research Foundation (NRF) of Korea [2010-0029138]
- Global Research Laboratory [2011-0021628]
- World Class University [R31-10013]
- Korea University
- Industrial Core Technology Development Program of MKE [10037397, 10033183]
- Basic Science Research Program of NRF [R11-2008-044-03004-0]
- KRICT [SI-1110]
- Nano R&D Program of NRF [2011-0019156, 2010-0019142]
- Development of Advanced Scientific Analysis Instrumentation Project of KRISS by MEST
- Pioneer Research Center Program of NRF [20100002195]
- Public Welfare & Safety Research Program of NRF [2011-0020957]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10033467] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [핵09A3504, 2008-2000107, R11-2008-044-03004-0, 2007-2002943] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.
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